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Nitroxides Increase the Detectable Amount of Nitric Oxide Released from Endothelial Cells
Journal of Biological Chemistry
Nitroxides are known to exert superoxide dismutasemimetic properties and to decrease O 2 . -and H 2 O 2 -mediated cytotoxicity. However, the effect of nitroxides on ⅐ NO homeostasis has not been studied yet. The present study investigates the effect of nitroxides on the detectable amount of ⅐ NO released by 3-morpholinosydnonimine (SIN-1) and cultured endothelial cells. Cultured bovine aortic and atrial endothelial cells stimulated with 10 M A23187 released a stable flux of ⅐ NO, as detected bydoi:10.1074/jbc.272.37.23076 pmid:9287307 fatcat:524wopc3kbd7jgcdjvspx53hmu