Synthesis, Characterization and Biological Evaluation of New Series of Schiff Bases Derived from Hexamethylenediamine as Potential Antibacterial and Antifungal Agents

KANGAH Niameke Jean-Baptiste, KODJO Charles Guillaume, OUATTARA Zana Adama, KABLAN Ahmont Landry Claude, DIBI Konan Jacques, KOUAME Bosson Antoine, Ziao Nahosse
2017 IRA-International Journal of Applied Sciences (ISSN 2455-4499)  
<div><p>We report herein synthesis, characterization and antimicrobial activity of four Shiff bases derived from hexamethylenediamine. Substitution of a nitro group on each aromatic ring in ortho, meta or para positions of N,N'-bis(phenylmethyl)hexane-1,6-diimineallowed to have a homogeneous series of positional isomers. These four symmetric diimine Schiff bases were characterized by conventional spectrometry methods (NMR, IR, MS), then tested against Gram-positive and Gram-negative bacterial
more » ... egative bacterial strains. Among them, compounds <strong>1b</strong>, <strong>1c</strong>, <strong>1d</strong> were found to be active against bacterial strain Staphylococcus aureus CIP with MIC value of 375μg/ ml, 187.5μg /ml and 375μg /ml respectively. Candida Albicans fungal strain showed resistance to all synthesized Schiff base compounds, butin the other hand, Candida glabrata has been sensitive to all compounds with MIC of 1500μg/ ml and one more time except <strong>1a</strong>.</p></div>
doi:10.21013/jas.v7.n2.p3 fatcat:ftkj3obx4je3bogstlid3lrp2u