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Phosphatidylinositol 3-Kinase/AKT-mediated Activation of Estrogen Receptor α
Journal of Biological Chemistry
Estrogen receptors (ERs) mediate most of the biological effects of estrogen in mammary and uterine epithelial cells by binding to estrogen response elements in the promoter region of target genes or through protein-protein interactions. Anti-estrogens such as tamoxifen inhibit the growth of ER-positive breast cancers by reducing the expression of estrogen-regulated genes. However, anti-estrogen-resistant growth of ER-positive tumors remains a significant clinical problem. Here we show thatdoi:10.1074/jbc.m010840200 pmid:11139588 fatcat:rfgzio5zejf4xajz32zymgoqva