Advances in autism genetics: on the threshold of a new neurobiology

Brett S. Abrahams, Daniel H. Geschwind
2008 Nature reviews genetics  
Identification of novel dyslexia candidate genes through the analysis of a chromosomal deletion Genome-wide association study of motor coordination problems in ADHD identifies genes for brain and muscle function A theoretical molecular network for dyslexia: integrating available genetic findings Integrated genome-wide association study findings: identification of a neurodevelopmental network for attention deficit hyperactivity disorder AKAPs integrate genome-wide association study findings for
more » ... utism spectrum disorders Summary and general discussion Nederlandse samenvatting (Dutch summary) List of publications Acknowledgements Curriculum vitae PhD thesis titles in Donders Graduate School of Cognitive Neuroscience series General introduction and outline of the thesis 27 91 139 11 A BSTRACT Dyslexia is the most common childhood learning disorder and it is a significantly heritable trait. At least nine chromosomal loci have been linked to dyslexia, and additional susceptibility loci on other chromosomes have been suggested. Within two of these loci, D Y X 1 C 1 (15q21 ) and R O B O 1 (3p12) have recently been proposed as dyslexia candidate genes through the molecular analysis of translocation breakpoints in dyslexic individuals carrying balanced chromosomal translocations. Moreover, genetic association studies have indicated a cluster of five dyslexia candidate genes in another linkage region on chromosome 6p22, although there is currently no consensus about which of these five genes contributes to the genetic susceptibility for dyslexia. In this article, we report the identification of four new dyslexia candidate genes (P C N T , D IP 2A , S 1 0 0 B and P R M T 2) on chromosome region 21q22.3 by FISH and SNP microarray analyses of a very small deletion in this region, which cosegregates with dyslexia in a father and his three sons. Key w ords: dyslexia; candidate genes; chromosome region 21q22.3 29 * position as mapped onto the Ensembl Human Genome Browser, version 45.
doi:10.1038/nrg2346 pmid:18414403 pmcid:PMC2756414 fatcat:77z5yb35snffjcmrhoekpdflmq