Bone mineral density in patients with systemic sclerosis and its association with hand involvement

Amira A. Shahin, Hania S. Zayed, Safaa Sayed, Waleed Gomaa
2013 Egyptian Rheumatologist  
Aim of the work: The aim of the present study is to assess bone mineral density (BMD) in systemic sclerosis (SSc) patients and to determine associated factors. Patients and methods: Sixty-five female SSc patients (mean age 39.5 ± 13.5 years, disease duration 7.3 ± 5.9 years), and forty age-and sex-matched controls were included. Forty-seven patients had limited SSc and 18 had diffuse type. Patients were subjected to clinical and functional assessment. BMD was quantified at the distal radius,
more » ... e distal radius, femoral neck and lumbar spine (L2-4) by dual energy X-ray absorptiometry. Results: SSc patients had a higher frequency of osteoporosis at the distal radius and osteopenia at the lumbar spine (p = 0.001 and 0.002, respectively), but the BMD at the femoral neck was not significantly different from the control group. Patients with osteoporosis at the distal radius had a significantly higher frequency of hand deformities (p < 0.05) and higher functional scores reflecting more disability than patients without (p = 0.01), while patients with osteoporosis at the lumbar spine were significantly older (p < 0.001) and had a longer disease duration than those without (p = 0.001). No associations were found between menopausal status, SSc subtype, skin score, internal organ affection and osteoporosis at the three skeletal sites.
doi:10.1016/j.ejr.2013.08.001 fatcat:5srygpg47faudix5y3buut56hy