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5-Azacytidine changes gene expression and causes developmental arrest of early chick embryo
1994
International Journal of Developmental Biology
Methylation of DNA appears to be an important maintenance mechanism for inhibiting gene expression during development in vertebrates. 5-azacytidine (5-azaC) is used as an experimental tool for demethylation and it induces differentiation in various systems. In the chick embryo, the first cellular migrations signal the onset of primitive streak and gastrula formation and result in neural induction and morphogenesis of the embryonic axis. In the present work with the early chick embryo, 5-azaC
pmid:7540035
fatcat:p2tppncysrckdpoutjpxc4emlq