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Sp1 Activates and Inhibits Transcription from Separate Elements in the Proximal Promoter of the Human Adenine Nucleotide Translocase 2 (ANT2) Gene
Journal of Biological Chemistry
Expression of the adenine nucleotide translocator 2 (ANT2) gene is growth regulated. We report a feature of the ANT2 promoter that involves a novel regulatory function for the Sp1 transfactor. We show that expression from the ANT2 proximal promoter is modulated through three Sp1 elements, two of which activate and one of which partially inhibits transcription. The inhibitor site, box C, is juxtaposed to transcription start (nucleotides ؊7 to ؊2). Sp1 bound to box C decreases transcriptiondoi:10.1074/jbc.271.31.18925 pmid:8702555 fatcat:luc4o2rjdre5xef24biu6j6vp4