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This paper introduces a new method to quantify and characterize shape changes during early facial development without the use of landmarks. Landmarks are traditionally used in morphometric analysis, but very few can be identified reliably across all stages of embryonic development. This method uses deformable registration to produce a dense vector field describing the point correspondences between two images. Low and mid-level features are extracted from the deformable vector field to finddoi:10.1109/iembs.2011.6091276 pmid:22255499 pmcid:PMC3261520 dblp:conf/embc/RolfeSCMC11 fatcat:vruswvnq4reudotwlgvkptgwti