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Endothelin 1 transcription is controlled by nuclear factor-kappaB in AGE-stimulated cultured endothelial cells
2000
Diabetes
ET-1 gene linked to a reporter gene confirmed that AGE induced ET-1 promoter activity. Electrophoretic mobility shift assay confirmed AGEinducible binding of members of the nuclear factor-b (NF-B) family to a potential binding site at -2,090 bp. Binding was functionally significant because overexpression of the cytoplasmic inhibitor of NF-B or deletion of the NF-B binding site reduced ET-1 induction, whereas overexpression of NF-B p65 induced ET-1 even in the absence of AGEs. Thus, ET-1
doi:10.2337/diabetes.49.9.1561
pmid:10969841
fatcat:7dh6bhl6xzcgbd6oxzy5bdqqhm