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Beyond the Single SNP: Emerging Developments in Mendelian Randomization in the "Omics" Era
2014
Current Epidemiology Reports
Mendelian randomization (MR) is an innovative epidemiological approach that uses genetic variants as proxies for environmental exposures to provide unbiased estimates of the causal effect of a risk factor on disease. The explosion in availability of high-throughput biological data has resulted in increasing numbers of MR studies, novel extensions to the traditional single-SNP MR approach, and the potential to incorporate new-generation biological "omics" data (such as genome-wide genotype data,
doi:10.1007/s40471-014-0024-2
fatcat:jfjrjlszzbfwvha6ltweg5xoh4