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Macrophage-Mediated Renal Injury Is Dependent on Signaling via the JNK Pathway
Journal of the American Society of Nephrology
Macrophage accumulation is a prominent feature in most forms of human glomerulonephritis and correlates with renal dysfunction. Macrophages can directly mediate acute renal injury in animal models, but the mechanisms of macrophage activation required for mediating renal injury are unknown. This study examined whether activation of the Jun amino terminal kinase (JNK) signaling pathway is necessary for macrophage-mediated renal injury. An adoptive transfer model was used in which rats weredoi:10.1097/01.asn.0000131272.06958.de pmid:15213265 fatcat:avszh4wq4zb2lmkufiyuoe3xwi