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The mutagenic effect of a common analgesic drug, paracetamol (PC) was evaluated in vivo using sister chromatid exchange in mouse bone marrow and chromosomal aberration analysis in both somatic and germ cells. For chromosomal aberration analysis PC was administrated orally by gavage as a single and repeated doses (100, 200, 400, 800 mg/kg b.wt.). PC induced a significant increase in the percentage of chromosomal aberrations in bone-marrow and spermatocytes which was dose and time dependent.doi:10.1508/cytologia.68.133 fatcat:w6jg6vh3z5crpohf4jxwq2hygm