Mutagenic Evaluation of Paracetamol in Somatic and Germ Cells of Mice

Ayman A. Farghaly
The mutagenic effect of a common analgesic drug, paracetamol (PC) was evaluated in vivo using sister chromatid exchange in mouse bone marrow and chromosomal aberration analysis in both somatic and germ cells. For chromosomal aberration analysis PC was administrated orally by gavage as a single and repeated doses (100, 200, 400, 800 mg/kg b.wt.). PC induced a significant increase in the percentage of chromosomal aberrations in bone-marrow and spermatocytes which was dose and time dependent.
more » ... ime dependent. Single oral treatment with PC also induced a dose dependent increase in SCE's frequency in mouse bone marrow cells. Such frequency was found to be statistically significant at the doses 400, 800 mg/kg b.wt. The present study indicates that PC was genotoxic in vivo in somatic and germ cells of mice.
doi:10.1508/cytologia.68.133 fatcat:w6jg6vh3z5crpohf4jxwq2hygm