IMGT unique numbering for immunoglobulin and T cell receptor constant domains and Ig superfamily C-like domains

Marie-Paule Lefranc, Christelle Pommié, Quentin Kaas, Elodie Duprat, Nathalie Bosc, Delphine Guiraudou, Christelle Jean, Manuel Ruiz, Isabelle Da Piédade, Mathieu Rouard, Elodie Foulquier, Valérie Thouvenin (+1 others)
2005 Developmental and Comparative Immunology  
IMGT, the international ImMunoGeneTics information system w ( provides a common access to expertly annotated data on the genome, proteome, genetics and structure of immunoglobulins (IG), T cell receptors (TR), major histocompatibility complex (MHC), and related proteins of the immune system (RPI) of human and other vertebrates. The NUMEROTATION concept of IMGT-ONTOLOGY has allowed to define a unique numbering for the variable domains (V-DOMAINs) and for the V-LIKE-DOMAINs.
more » ... n this paper, this standardized characterization is extended to the constant domains (C-DOMAINs), and to the C-LIKE-DOMAINs, leading, for the first time, to their standardized description of mutations, allelic polymorphisms, two-dimensional (2D) representations and tridimensional (3D) structures. The IMGT unique numbering is, therefore, highly valuable for the comparative, structural or evolutionary studies of the immunoglobulin superfamily (IgSF) domains, V-DOMAINs and C-DOMAINs of IG and TR in vertebrates, and V-LIKE-DOMAINs and C-LIKE-DOMAINs of proteins other than IG and TR, in any species. q
doi:10.1016/j.dci.2004.07.003 pmid:15572068 fatcat:yjiotyragzhx5kvr3eip3ntgay