Nephrogenic fibrosing dermopathy

ArunC Inamadar, RavindraM Madraki, BR Yelikar, S Ragunatha, Aparna Palit
2009 Indian Journal of Dermatology, Venereology and Leprology  
An adult female patient on hemodialysis for chronic renal failure presented with large, brownish, and indurated plaques with bound-down skin on both lower limbs and abdomen along with difficulty in movement of the legs. Histopathological features revealed thick collagen bundles admixed with mucin and intercalating spindle-like cells characteristic of nephrogenic fibrosing dermopathy (NFD). Immunohistochemical study showed prominent CD68 positivity and weak CD34 positivity suggesting that the
more » ... ques were more than 20-weeks old. NFD in patients with chronic renal failure of unknown cause is a poor prognostic indicator. Early detection before the development of contracture and prompt treatment of NFD and underlying renal failure may reverse this disabling condition.
doi:10.4103/0378-6323.45224 pmid:19172035 fatcat:5t4jy5hz6rgz3c2zcamlsavnaq