Porous chitosan by crosslinking with tricarboxylic acid and tuneable release

Yonghong Yang, Guanhong Chen, Patricia Murray, Haifei Zhang
2020 SN Applied Sciences  
Chitosan hydrogels crosslinked with 1,3,5-benzene tricarboxylic acid (BTC) are readily prepared at room temperature by adding aqueous chitosan solution dropwise into BTC-ethanol solution. Highly interconnected porous chitosan materials are subsequently prepared by freeze-drying the chitosan hydrogels. These chitosan materials show porous structures with smaller pores than conventionally prepared chitosan hydrogels via crosslinking with NaOH, genipin or sodium triphosphate. This method of
more » ... chitosan hydrogels with BTC provides the advantage of facile encapsulation of both hydrophobic and hydrophilic compounds, as demonstrated with the model dyes (Oil Red O and Rhodamine B). The release of the hydrophilic dye from the chitosan hydrogels is demonstrated and can be tuned by BTC/chitosan concentrations and the hydrogel drying methods. However, the release of encapsulated hydrophobic dye is negligible.
doi:10.1007/s42452-020-2252-z fatcat:mpvadoncffez7hsjhe55bpur7i