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In rats and baboons, the hepatotoxicity of chronic ethanol consumption is exacerbated by β-carotene feeding, but the mechanism of this adverse effect is unknown. In this study, the toxicity of β-carotene and acetaldehyde was documented by the MTT test (an assay of reduction of tetrazolium to formazan) and by lactate dehydrogenase (LDH) leakage. In HepG2 cells, β-carotene or acetaldehyde inhibited mitochondrial reduction function as indicated by a decrease of the MTT test. β-Carotene wasdoi:10.1093/alcalc/36.4.281 pmid:11468125 fatcat:myx5jsfjcvgufdgmyl6uqra2sy