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Leptin deficient rats develop nonalcoholic steatohepatitis with unique disease progression
Nonalcoholic steatohepatitis (NASH) is an aggressive liver disease threatening public health, however its natural history is poorly understood. Unlike ob/ob mice, Lep∆I14/∆I14 rats develop unique NASH phenotype with steatosis, lymphocyte infiltration and ballooning after postnatal week 16. Using Lep∆I14/∆I14 rats as NASH model, we studied the natural history of NASH progression by performing an integrated analysis of hepatic transcriptome from postnatal week 4 to 48. Leptin deficiency resultsdoi:10.1101/594978 fatcat:qso3yp6zwfdejhhm7niyiz7sn4