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Simple, Scalable Proteomic Imaging for High-Dimensional Profiling of Intact Systems
2015
Cell
Combined measurement of diverse molecular and anatomical traits that span multiple levels remains a major challenge in biology. Here, we introduce a simple method that enables proteomic imaging for scalable, integrated, high-dimensional phenotyping of both animal tissues and human clinical samples. This method, termed SWITCH, uniformly secures tissue architecture, native biomolecules, and antigenicity across an entire system by synchronizing the tissue preservation reaction. The heat- and
doi:10.1016/j.cell.2015.11.025
pmid:26638076
pmcid:PMC5275966
fatcat:gomrshdzavgzxilh6ymju7uhha