Peripheral Artery Disease and Kidney Function in Hypertensive Patients

Carolina Sarmento, Telmo Pereira, João Maldonado, Jorge Conde
2013 Arquivos Brasileiros de Cardiologia  
Patients with peripheral arterial disease (PAD) have a high risk of developing cardiovascular events. There is a high prevalence of PAD in individuals with kidney disease and both are important risk factors for cardiovascular events. Objective: The aim of this study was to investigate the association between PAD and renal function in hypertensive patients. Methods: The sample consisted of 909 individuals with arterial hypertension. The presence of PAD was evaluated using the ankle-brachial
more » ... ankle-brachial index (ABI) method and renal function was assessed based on the estimated glomerular filtration rate (eGFR). The subjects were divided into groups, according to abnormal (ABI ≤ 0.9) and normal ABI (ABI 0.9-1.4). Results: The percentage of subjects with abnormal ABI was 8%. In the group of individuals with abnormal ABI, prevalence of CKD was 23.4%, compared to a prevalence of 11.2% in patients with normal ABI. Multivariable logistic regression analysis, after adjusting the model to the conventional cardiovascular risk factors, identified a statistically significant and independent effect of eGFR on the likelihood of developing PAD, with an OR of 0.987 (CI: 0.97-1.00). Conclusion: An independent association between PAD and chronic kidney disease was observed in the present study. Therefore, the combination of an accurate diagnosis of kidney disease and routine ABI evaluation could constitute a more efficient means to identify subclinical PAD, allowing individuals to benefit from early interventions, aiming at reducing cardiovascular risk. (Arq Bras Cardiol. 2013;100(4):362-367)
doi:10.5935/abc.20130052 fatcat:bmwetx6ebradpawacc3ko4djei