Rhythmicity of Intestinal IgA Responses Confers Oscillatory Commensal Microbiota Mutualism [article]

Hugo A Penny, Rita G Domingues, Maria Z Krauss, Felipe Melo-Gonzalez, Suzanna Dickson, James Parkinson, Madeleine Hurry, Catherine Purse, Emna Jegham, Cristina Godinho-Silva, Miguel Rendas, Henrique Veiga-Fernandes (+7 others)
2021 bioRxiv   pre-print
Mutualistic interactions with the commensal microbiota are enforced through a range of immune responses that confer metabolic benefits for the host and ensure tissue health and homeostasis. Immunoglobulin (Ig)A responses directly determine the composition of commensal species that colonize the intestinal tract but require significant metabolic resources to fuel antibody production by tissue-resident plasma cells. Here we demonstrate IgA responses are subject to diurnal regulation by
more » ... ved metabolic cues and a cell-intrinsic circadian clock. Rhythmicity in IgA secretion conferred oscillatory patterns on the commensal microbial community and its associated metabolic activity, resulting in changes to metabolite availability over the course of the circadian day. Our findings suggest circadian networks comprising intestinal IgA, the diet and the microbiota align to ensure metabolic health.
doi:10.1101/2021.10.11.463908 fatcat:yzht67jv7bhvdpgtzssw7bvimi