Interstitial Lung Disease in Systemic Lupus Erythematosis: A case report

Nikita Malhotra, Santwana Chandrakar, Varun Shetty
2017 Annals of International medical and Dental Research  
Systemic lupus erythematosus (SLE) is a chronic inflammatory disease of unknown etiology that can affect virtually every organ in the body. Presentation of a patient can vary considerabaly. Many a times, pleurisy, coughing, and/or dyspnea are the first clues either to lung involvement or to SLE itself. In this case report we present a patient who was diagnosised with SLE along with pulmonary diagnosis of interstitial lung diasese (ILD). Case report: A 40 year old female presented with swelling
more » ... nted with swelling of both lower extremities, facial puffiness for one month and dry cough for past 3 years. Examination revealed painful joints and bilateral fine crepts at the bases of lungs. Patient's ANA and anti-double stranded DNA indicated SLE. Pulmonary function test showed restrictive pattern of lung disease compatible with interstitial lung disease (ILD), which was supported by High resolution computed tomography thorax. 2D echocardiography revealed mild tricuspid rgurgitation and pulmonary artery systolic pressure of 80 mm of mercury. Based on the clinical and laboratory findings present in this patient, a final diagnosis of SLE with ILD and pulmonary hypertension was made. Treatment included immunosuppresive therapy, mycophenolate mofetil, pirfenidone and sildenafil. Mild improvement of respiratory symptoms was noted in the patient. Conclusion: Careful history taking, clinical examination and appropriate clinical investigations helped us in clinching the diagnosis. Further research is required to understand the mechanisms responsible for ILD in SLE patients and how these cases can be treated effectively.
doi:10.21276/aimdr.2017.3.6.me4 fatcat:yfyqsuj7zbbgro7fnaghjtqkmy