Cardiomyopathy: Getting Bigger All the Time - Lessons Learned about Heart Disease from Tropomyosin [chapter]

David F. Wieczorek
2021 Cardiomyopathy - Disease of the Heart Muscle [Working Title]  
In 1990, John and Christine Seidman uncovered the genetic association between mutations in sarcomeric contractile proteins and hypertrophic cardiomyopathy. Since then, the increase in knowledge and understanding of this disease has increased exponentially. Although pathologies associated with the various cardiomyopathies are vastly different, in some cases, the same proteins are causative, but with different genetic mutations. The focus of this article will be on hypertrophic and dilated
more » ... yopathies, which are often caused by mutations in sarcomeric contractile proteins. Tropomyosin, a thin filament protein, serves as a paradigm to illustrate how different mutations within the same protein can generate the hypertrophic or dilated cardiomyopathic condition. As such, the significant advances in information derived from basic science investigations has led to the development of novel therapeutics in the treatment of these pathological diseases. This article will illustrate linkages which occur to bridge scientific advances to clinical treatments in cardiomyopathic patients.
doi:10.5772/intechopen.95509 fatcat:yveyh6woqbgklgbhqp64m7xm5m