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<div> <p>A facile one-pot strategy for <sup>13</sup>CN and <sup>14</sup>CN exchange with aryl, heteroaryl, and vinyl nitriles using a Ni phosphine catalyst and BPh<sub>3</sub> is described. This late-stage carbon isotope exchange (CIE) strategy employs labeled Zn(CN)<sub>2</sub> to facilitate enrichment using the non-labeled parent compound as the starting material, eliminating <i>de novo</i> synthesis for precursor development. A broad substrate scope encompassing multiple pharmaceuticals isdoi:10.26434/chemrxiv.13724023.v2 fatcat:buglqlkkz5cx7ep5n6ssvxwcoa