Oral Abstracts

2021 Glia  
The development of the most complex biological organ, the Central Nervous System (CNS) comprising the brain and the spinal cord, is one of the most fascinating endeavors undertaken by evolution, and one of the most interesting topics to understand our own human complexity. Recent technological advances, including transcriptomic profiling of single cells, precise cell-lineage tracing, refined genetic tools for functional studies, and unprecedented imaging of the developing CNS, have given us a
more » ... eper inside into the variety of cell-types and the molecular mechanisms involved their generation, deployment, and homeostasis. In this course, we will look into the mechanisms involved in the generation of different neural cell-types focusing on glial cells, including the role of transcription regulators driving commitment toward oligodendroglia and astrocytes, the role of radial glia as the neural stem cells, and the mechanisms leading to the generation of different neural subtypes, such as cell-cell interaction, patterning, and timing. We will end up discussing how this knowledge is leading to optimise different protocols inducing neurogenesis and gliogenesis in the-dish, by reproducing normal development, or by shortcuts driving the generation of a neural subtype through reprogramming from one cell-type to another, with these ex-vivo models helping to unravel the specific changes proper to human CNS development during physiological and pathological conditions.
doi:10.1002/glia.24035 pmid:34173981 fatcat:q2h3ttvpxnfcxds4p6jy6h7mcq