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In a recent study, Fayssoil et al. investigated the relation between serum/urine heteroplasmy rates and clinical manifestations at onset and major adverse events (MAE) during follow-up in a retrospective study of 43 patients carrying the m.3243A>G mutation1 MAE included strokelike episodes (SLEs), status epilepticus, heart failure, renal failure, and intestinal pseudo-obstruction1 We want to add some comments and concerns.doi:10.15520/jcmro.v1i09.107 fatcat:uua75uef4vajriaanjpwvqxuza