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Targeted Cleavage and Polyadenylation of RNA by CRISPR-Cas13
[article]
2019
bioRxiv
pre-print
Post-transcriptional cleavage and polyadenylation of messenger and long noncoding RNAs is coordinated by a supercomplex of ~20 individual proteins within the eukaryotic nucleus. Polyadenylation plays an essential role in controlling RNA transcript stability, nuclear export, and translation efficiency. More than half of all human RNA transcripts contain multiple polyadenylation signal sequences that can undergo alternative cleavage and polyadenylation during development and cellular
doi:10.1101/531111
fatcat:pd2tuu2djvef7osef7nsxwkqiy