2 0 1 2 2 Journal of Shanghai Normal University4 Natural SciencesI Fed . 2 0 1 2

Yu Liang, Si-Jia Xue
2011 unpublished
eA novel compound N-44-methylbenzylI-3 5-bis44-chlorobenzylideneI-4-pip-eridone was synthesized with 4-methylbenzylamine as raw materials via a series of Michael addition Dieckmann condensation hydrolysis decarboxylation and Aldol condensation. The structure was confirmed by elemental analysis 1 H NMR IR ESI and single-crystal X-ray diffraction. The crystal belongs to the monoclinic system with space group P241I corresponding to a = 17. 1226416I b = 6. 2839646I c = 21. 46842I α = 90° β = 99.
more » ... α = 90° β = 99. 753° γ = 90° V = 2276. 5 44 I 3 Z = 4 D c = 1. 308 g / cm 3 = 0. 304 mm-1 M r = 448. 36 F i 000I = 936 S = 1. 019 the final R = 0. 0585 and wR = 0. 1456. The molecule was nonplanar and the piperidine ring exhibited a sofa conformation. The carbon-carbon double bonds in the compound were both E-configuration. Neither intra-nor in-termolecular hydrogen bonds was identified in the crystal structure. Assay-based antiproliferative activity study using leukemic cell lines K562 revealed that the compound had high effectiveness in inhibiting leukemia K562 cells proliferation. Key wordse4-piperidonez synthesisz crystal structurez inhibitionz leukemia K562 CLC numbereO 741 + . 6 Document codeeA
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