Studies on the breakdown of glycogen in the lysosomes: the effects of hydrocortisone

S A Kalamidas, O B Kotoulas
2000 Histology and Histopathology  
The effects of hydrocortisone on newborn rat liver were studied by using biochemical assays, electron microscopy and quantitative morphometry. Hydrocortisone increased the number of lysosomes in the hepatocytes. Most of the lysosomes represented glycogen-containing autophagic vacuoles. The glucocorticoid also increased the activity of the liver glycogen-hydrolyzing acid glucosidase and the breakdown of glycogen inside lysosomes. The activity of the liver acid mannose 6-phosphatase was
more » ... atase was decreased. This may be related to the stimulation of autophagic mechanisms in the newborn rat hepatocytes.
doi:10.14670/hh-15.29 pmid:10668192 fatcat:q2or3g2ul5fxpoyoze45hdelxe