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Varlociraptor: enhancing sensitivity and controlling false discovery rate in somatic indel discovery
2020
Genome Biology
Accurate discovery of somatic variants is of central importance in cancer research. However, count statistics on discovered somatic insertions and deletions (indels) indicate that large amounts of discoveries are missed because of the quantification of uncertainties related to gap and alignment ambiguities, twilight zone indels, cancer heterogeneity, sample purity, sampling, and strand bias. We provide a unifying statistical model whose dependency structures enable accurate quantification of
doi:10.1186/s13059-020-01993-6
pmid:32345333
fatcat:syimcl2flvfffiomxnm3aup7aq