Effects of daytime melatonin infusion in young adults

Cameron J. Van Den Heuvel, David J. Kennaway, Drew Dawson
1998 American Journal of Physiology. Endocrinology and Metabolism  
Van den Heuvel, Cameron J., David J. Kennaway, and Drew Dawson. Effects of daytime melatonin infusion in young adults. Am. J. Physiol. 275 (Endocrinol. Metab. 38): E19-E26, 1998.-Daytime oral melatonin typically exerts soporific and thermoregulatory effects; however, it is not clear whether these effects reflect the normal physiological response to endogenous nocturnal melatonin production. We infused melatonin at doses that produced physiological and supraphysiological steady-state levels in
more » ... y-state levels in 24 young adults during two daytime bed rest protocols. From 1000 to 1630, subjects were infused intravenously with saline or melatonin in counterbalanced order. Each group of eight subjects received melatonin (and saline) infusions at one dose rate: 0.04 µg·h Ϫ1 · kg body wt Ϫ1 (low), 0.08 µg · h Ϫ1 ·kg Ϫ1 (medium), or 8.0 µg·h Ϫ1 ·kg Ϫ1 (high). Low and medium melatonin infusions produced plasma and saliva levels within the normal nocturnal range observed in young adults. These levels were not associated with any changes in rectal, hand, forehead, or tympanic temperatures or with subjective sleepiness. High melatonin produced supraphysiological plasma and saliva levels and was associated with a significant attenuation in the daytime increase in rectal temperature, significantly increased hand temperature, and greater sleepiness. It is not yet clear whether the thermoregulatory and soporific effects of daytime supraphysiological melatonin administration are equivalent to the physiological responses to endogenous melatonin. core temperature; thermoregulation; sleepiness; intravenous administration; soporific effects; physiology The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
doi:10.1152/ajpendo.1998.275.1.e19 fatcat:qcu5zmfv7zgwjffmguv6hmz6va