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Enzyme-catalyzed Mechanism of Isoniazid Activation in Class I and Class III Peroxidases
2004
Journal of Biological Chemistry
There is an urgent need to understand the mechanism of activation of the frontline anti-tuberculosis drug isoniazid by the Mycobacterium tuberculosis catalase-peroxidase. To address this, a combination of NMR spectroscopic, biochemical, and computational methods have been used to obtain a model of the frontline anti-tuberculosis drug isoniazid bound to the active site of the class III peroxidase, horseradish peroxidase C. This information has been used in combination with the new crystal
doi:10.1074/jbc.m402384200
pmid:15231844
fatcat:m2gnvnbb3vh33ap3gsp7r2v5ni