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The reactivity of N-[(2-oxoindolin-3-ylidene)-2-oxiacetyl] amino acids
2015
Vìsnik farmacìï
The reactivity of N-[(2-oxoindolin-3-ylidene)-2-oxiacetyl] amino acids has been investigated in the reversible conditions by studying their acid-base properties in the binary solvent of dioxane -water (60 volume % of dioxane) at 25°С. The experimental compounds have been proven to be weak dibasic acids. Their рКа values have been determined by Noyes method. The correlation of these values to both of the reactive sites (СООН-and ОН-groups) has been performed. It has been shown that each CH 2
doi:10.24959/nphj.15.2050
fatcat:uzcpesq5ljh4bpdikkszcnqhge