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Down-regulation of MARCKS-related Protein (MRP) in Macrophages Infected withLeishmania
1999
Journal of Biological Chemistry
Leishmania, a protozoan parasite of macrophages, has been shown to interfere with host cell signal transduction pathways including protein kinase C (PKC)dependent signaling. Myristoylated alanine-rich C kinase substrate (MARCKS) and MARCKS-related protein (MRP, MacMARCKS) are PKC substrates in diverse cell types. MARCKS and MRP are thought to regulate the actin network and thereby participate in cellular responses involving cytoskeletal rearrangement. Because MRP is a major PKC substrate in
doi:10.1074/jbc.274.24.16782
pmid:10358020
fatcat:fgclyyshsbckpo4uof3kxf5qhu