Overexpression of CD44v8-10 in urinary exfoliated cells as an independent prognostic Predictor in patients with urothelial cancer

2001 The Japanese Journal of Urology  
【 Objectives 】 The ebjective of this study was to examine whether the transcriptional levels of CD44v8−10 relative to standard CD44 isoforrn( v9 −10 / s ra 巳 io ) cou 】 d predict the extent and prognosis of urothelial cancer . 【 Methods 】 v8 − 10/ s ratios were measured in urine sumples (【 50 with urothe ] jal canoer and 50 with benign uro 】 ogjcal disease ) by RT ・ PCR using the set of primers that can amplyfy all CD44 splice variant isoforms .【Results】The mean values of v8 −10 / s ratios in
more » ... ine frorn invasiv 巳 cancer patients was significantly higher than 山 ・ se fr ・m superficial cancer patients . Among superficial cancer patients , the disease −free survival rate of patients with elevated v8 −10 / s levels was significantly Iower than that of pStients with normal levels . Moreover , among patlents with advanced disease who underwent complete res tion , the disease − free survival rate of patients with elevated v8 ・ 10/ s levels was sjgnificantly lower than thut of paticnts with normal levels 、 【 Conclusions 】Elevation of v8 −10 /s level in urine could be uscd as a novel prognostic predicし or and disease extent Ln urothelia 且ca 囗 cer patjents . urothelial cancer CD44 urine
doi:10.5980/jpnjurol.92.354_3 fatcat:x3rhuw55rzhvlejvg5n5uhc3ee