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In vivo electron paramagnetic resonance imaging of tumor heterogeneity and oxygenation in a murine model
Nitroxides are redox-sensitive probes, which are useful in noninvasively delineating tissue heterogeneity especially with respect to metabolic activity and tissue oxygenation. Recent studies have shown that nitroxides are in vitro and in vivo radioprotectors and selectively protect normal tissue compared to tumor tissue. It has been postulated that the basis for selective radioprotection of normal tissues is greater bioreduction of nitroxides in tumor tissue compared to normal tissue. The aimpmid:9537265 fatcat:s2btv6ai4javrchu6zfuiqadoq