Unfavorable Blood Rheology is Closely Associated with Arterial Stiffness in Obese Patients

Noriko SATOH, Kazuhiko KOTANI, Hiromichi WADA, Akihiro HIMENO, Sayaka SHIMADA, Yousuke SASAKI, Kazunori YAMADA, Akira SHIMATSU, Koji HASEGAWA
2009 Endocrine journal  
on atherosclerosis formation in obesity, it is of interest in the relationship between the rheological/microcirculatory conditions as assessed by the MC-FAN and peripheral/cetral arterial stiffness as assessed by pulsewave velocity (PWV) [8] . Our study was aimed to observe the relationship extent among obese patients. Materials and Methods A total of 109 Japanese obese patients (body mass index (BMI) ≥ 25, 45 men and 64 women, mean age 51.3 years) were enrolled, and consisted of 88
more » ... patients, 49 diabetic patients and 67 dyslipidemia patients. They were classified as having MS or not (non-MS) according to the definition and diagnostic criteria of the MS proposed by the Japan Metabolic Syndrome Criteria Study Group in 2005 as previously described [9] . MS is defined as the presence of central adiposity (waist circumference of ≥ 85 cm for men and ≥ 90 cm for women) plus two or more of the following three criteria: 1) raised concentration Abstract. Little information on the relationship between blood rheology and atherosclerosis indicators in obese patients is available. We examined blood rheology as assessed by the blood passage time (BPT) with the microchannel method in 109 obese patients. BPT was correlated well with the extent of each metabolic syndrome component. A multivariate regression analysis revealed that the independent contributors to BPT were pulse-wave velocity, an index of arterial stiffness, body mass index and red blood cell. Furthermore, weight reduction intervention significantly decreased BPT. Assessment of rheology may be associated with pulse-wave velocity, and useful to manage obese patients.
doi:10.1507/endocrj.k09e-167 pmid:19550074 fatcat:esvdnqrrlrffzkibpxoxdzolga