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The presence of both estrogen receptor ␣ (ER␣) and ER␤ in vascular cells has greatly increased the complexity of potential estrogen regulatory pathways in the cardiovascular system. Here, human umbilical vein endothelial cells were engineered using adenovirus vectors to express either ER␣ or ER␤. The activities of ER␣ and ER␤ were compared in three distinct gene regulatory pathways, including inhibition of IL-1␤ induction of E-selectin expression, inhibition of basal endothelin-1 production,doi:10.1210/en.2002-220356 pmid:12239089 fatcat:f3r7kogurrertl6atztyfws73y