Objective: The present research work was to provide fast dissolving oral tablets of Lurasidone hydrochloride to enhance the solubility and thereby increase its onset of action. Method: Melt in mouth tablets of Lurasidone Hydrochloride were prepared by Direct compression method using Superdisintegrants; Crospovidone, Croscarmellose sodium, Sodium starch glycolate and disintegrant Pregelatinized starch in three different concentrations of 3%, 4%, 5% respectively and combination of

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... ts in 1:1 ratio with microcrystalline cellulose along with directly compressible mannitol to enhance mouth feel. The drug and drug with polymers after being subjected to FT-IR Studies were found to be interaction free. Pre-compression parameters of the blend and Post-compression parameters of the prepared batches were evaluated and found to be satisfactory. Results: Formulation containing Croscarmellose sodium as superdisintegrant was fulfilling all the parameters satisfactorily. It was observed that disintegration time decreases with increase in the concentration of superdisintergrant from 3% to 5% w/w. The formulation F9 and CF2 exhibited satisfactory release profile at each time point. All the formulations showed a disintegration time of less than 50 seconds. Among all, F9 containing 5% croscarmellose sodium showed a least disintegration time of 25 seconds with a drug release of 99.92% within 10 minutes and CF2 containing 1:1 ratio of croscarmellose sodium and crospovidone showed a least disintegration time of 28 seconds with a drug release of 99.84% within 10 minutes. Hence, F9 and CF2 were considered as the best formulations. Stability studies were conducted for formulations for 3 months. Conclusion: It was concluded that melt in mouth tablets of Lurasidone Hydrochloride can be successfully formulated with increase onset of action.