Toward better drug repositioning: prioritizing and integrating existing methods into efficient pipelines

Guangxu Jin, Stephen T.C. Wong
2014 Drug Discovery Today  
Recycling old drugs, rescuing shelved drugs and extending patents' lives make drug repositioning an attractive form of drug discovery. Drug repositioning accounts for approximately 30% of the newly US Food and Drug Administration (FDA)-approved drugs and vaccines in recent years. The prevalence of drug-repositioning studies has resulted in a variety of innovative computational methods for the identification of new opportunities for the use of old drugs. Questions often arise from customizing or
more » ... optimizing these methods into efficient drug-repositioning pipelines for alternative applications. It requires a comprehensive understanding of the available methods gained by evaluating both biological and pharmaceutical knowledge and the elucidated mechanism-of-action of drugs. Here, we provide guidance for prioritizing and integrating drug-repositioning methods for specific drug-repositioning pipelines.
doi:10.1016/j.drudis.2013.11.005 pmid:24239728 pmcid:PMC4021005 fatcat:iuzx6laim5h63ezz7uto43xt6a