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Identification of a Tetramerization Domain in the C Terminus of the Vanilloid Receptor
2004
Journal of Neuroscience
TRPV1 (transient receptor potential vanilloid receptor subtype 1) is a member of the TRP channel family gated by vanilloids, protons, and heat. Structurally, TRPV1 appears to be a tetramer formed by the assembly of four identical subunits around a central aqueous pore. The molecular determinants that govern its subunit oligomerization remain elusive. Here, we report the identification of a segment comprising 684 Glu-721 Arg (referred to as the TRP-like domain) in the C terminus of TRPV1 as an
doi:10.1523/jneurosci.0202-04.2004
pmid:15190102
fatcat:y4525swrijfydnixk5d5ui576u