Natural Polymorphisms of HIV Type 2 pol Sequences from Drug-Naive Individuals

Ricardo Parreira, Filipa Monteiro, Elizabeth Pádua, João Piedade, Teresa Venenno, Maria Teresa Paixão, Aida Esteves
2006 AIDS Research and Human Retroviruses  
Until today, the susceptibility of human immunodeficiency virus type 2 (HIV-2) to protease and nucleosidic reverse-transcriptase inhibitors (PI and NRTI, respectively) has not been clearly documented. In this report we studied HIV-2 proviral sequences (n ‫؍‬ 30) from drug-naive patients. Our results revealed that several amino acid positions in the protease and reverse transcriptase coding sequence harbored residues that have been associated with drug resistance in HIV-1-infected patients. In
more » ... rticular, the M46I substitution in the protease was detected in 90% of the sequences analyzed, which, together with the other substitutions identified, may indicate a reduced susceptibility of HIV-2-infected drug-naive patients to PI. Furthermore, interpretation of genotypic data with four available algorithms, developed for interpretation of HIV-1 sequence data, suggested nonoverlapping profiles of drug resistance.
doi:10.1089/aid.2006.22.1178 pmid:17147507 fatcat:2hhx5kevqzgippewlvjcvxkxcm