Lung cancer is one of the most commonly diagnosed diseases in both men and women and the leading cause of cancer-related death worldwide. This study aims to investigate the effect of lung cancer on the role of some hematological criteria in patient serum. There were fifty (50) lung cancer patients (males and females) and forty (40) healthy subjects in the present study. The levels of some hematological parameters that include erythrocyte indices [red blood cell (RBCs) count, hemoglobin (Hb),

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... atocrit (HCT), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), mean corpuscular volume (MCV), and red cell distribution width (RDW)], leukocyte indices [total white blood cell (WBCs) count, neutrophil percentage (%), lymphocyte percentage (%)], and thrombocyte indices [platelet count and mean platelet volume (MPV)] was recorded. In general, the levels of all hematological criteria in the serum of lung cancer patients were significantly different (p<0.05) from those of the control groups. In conclusion, hematological measurements can provide important prognostic information for patients with lung cancer, and they are simple and readily available at medical centers.