Journal homepage: http://www.ijcmas.com Methicillin-resistant Staphylococcus aureus (MRSA) is one of the major causes of hospital-acquired infections worldwide. It is widespread in communities and prevalent in hospital and even amongst the livestock.The mortality and morbidity amongst patients with infections associated with MRSA are usually high owing to increasing resistance to several antibiotics. The resistant pattern of MRSA has not been clearly defined in Oleh. This study was designed to

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... etermine the incidence and antibiotics resistant pattern of MRSA from the healthy students in Oleh campus, south-southern Nigerian locality. Methods: Three hundred (300) specimens were collected and appropriate procedures were followed for identification and susceptibility testing. The MRSA was determined using Oxacillin antibiotic disc. Of the 300 nasal swab samples collected and screened, a total 164 (72.7%) of the isolates were found to be S. aureus based on morphology and biochemical tests. The incidence rate from female to male individuals were 78(57 %) and 87 (52 %) respectively. The incidence rate of MRSA and colonisation among healthy individuals in the community was 15.7% (47/300) and 28.7 % (47/164) of the S. aureus isolates. The antibiotic resistant pattern of MRSA isolates was ciprofloxacin ~ ofloxacin ~ amoxicillin clavulanate > gentamicin,> co-trimoxazole > chloramphenicol > erythromycin > streptomycin >amoxicillin Although, multi-drug resistant strains of S. aureus have been identified in this study, infections caused by S aureus infections could be treated with flouroquinolones and Gentamicin.