TGF-β1 869T/C Polymorphism and Ischemic Stroke: Sex Difference in Chinese

Hong-miao Tao, Guo-zhong Chen, Xiao-dong Lu, Gan-ping Chen, Bei Shao
2010 Canadian Journal of Neurological Sciences  
AbstractBackground:Inflammation plays a pivotal role in the pathogenesis of atherosclerosis and of cerebrovascular complications. Transforming growth factor-β (TGF-β) is a pleiotropic cytokine with a central role in inflammation. To investigate whether polymorphisms of the TGF-β1 gene can modify the risk of ischemic stroke (IS) in Chinese population, we conduct this hospital-based, case-control study.Methods:Transforming growth factor-β1 genotype was determined in 450 Chinese patients (306 male
more » ... patients (306 male and 144 female) with IS and 450 control subjects (326 male and 124 female).Results:Subjects carrying 869TT were susceptible to IS (odds ratio [OR] =1.58; P=0.003). Further analysis of IS data partitioned by gender revealed the female-specific association with 869T/C (OR=2.64; P=0.001).Conclusions:Findings suggest that the TT genotype of 869T/C might be a risk factor of IS in Chinese, especially in females.
doi:10.1017/s0317167100051477 fatcat:tbrfvtjlvzfslenwcy26nofk74