Aims Lower platelet activation by cryoenergy compared with radiofrequency (RF) energy was recently demonstrated immediately following ablation procedures of cardiac arrhythmias. Due to the delayed occurrence of cryolesions it is currently unknown, if cryoenergy and RF energy are associated with similar platelet activation and myocardial necrosis in the days after the procedure. Methods and results We enrolled 38 patients with common atrial flutter undergoing cavotricuspid isthmus ablation with

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... ither RF energy (n ¼ 23) or cryoenergy (n ¼ 13). Ten patients undergoing RF ablation and receiving aspirin served as antiplatelet control group. Troponin T and platelet surface protein expression of P-selectin were determined before and immediately after ablation as well as on day 1 and 2 thereafter. Rise in troponin T was amplified after RF ablation (0.50 + 0.37 mg/L) when compared with cryoablation (0.24 + 0.20 mg/L; P ¼ 0.024). In patients without aspirin, a significant increase in P-selectin expression was observed on day 1 after intervention in RF ablation compared with cryoablation (80 + 26 vs. 63 + 16 arbitrary units; P ¼ 0.048). Platelet activation was attenuated in patients receiving aspirin. Conclusion Successful ablation of atrial flutter with cryoenergy is associated with less myocardial necrosis and platelet activation compared with ablation with RF energy. Increased platelet activation following RF ablation can be attenuated by concomitant treatment with aspirin.