Expert consensus on clinical applications of high-frequency oscillations in epilepsy

Yuping Wang, Dong Zhou, Xiaofeng Yang, Xin Xu, Liankun Ren, Tao Yu, Wenjing Zhou, Xiaoqiu Shao, Zhixian Yang, Shuang Wang, Dezhi Cao, Chunyan Liu (+2 others)
2020 Acta Epileptologica  
Studies in animal models of epilepsy and pre-surgical patients have unanimously found a strong correlation between high-frequency oscillations (HFOs, > 80 Hz) and the epileptogenic zone, suggesting that HFOs can be a potential biomarker of epileptogenicity and epileptogenesis. This consensus includes the definition and standard detection techniques of HFOs, the localizing value of pathological HFOs for epileptic foci, and different ways to distinguish physiological from epileptic HFOs. The
more » ... t clinical applications of HFOs in epilepsy and the related findings are also discussed. HFOs will advance our understanding of the pathophysiology of epilepsy. Background High-frequency oscillations (HFOs) have become a new biomarker of epileptogenic zone in the brain. This expert consensus highlights the development of clinical applications of HFOs in the context of epilepsy as well as the findings, in the aim to provide guidance for epilepsyrelated clinical use of HFOs. Definition of HFOs and their standard detection techniques Definition of HFOs HFOs are oscillatory high-frequency (> 80 Hz) brain signals recorded by electroencephalography (EEG) due to the transient local-field potential (LFP) oscillations. HFOs are defined as having at least four oscillations with sinusoidal-like morphology in the filtered signal (> 80 Hz) with a root mean square amplitude increase of more than 5 times the standard deviation compared to background brain activity [1, 2] or with energy larger than the 95 percentile of the surrounding background [3] .
doi:10.1186/s42494-020-00018-w fatcat:4fvjv47lmfcwdgq7wnqfrvbjzi