Synergistic Effects of Cinnamomum camphora Leaves Extract against Clinical Isolated Methicillin-resistant Staphylococcus aureus
임상에서 분리한 메치실린 내성 황색포도상구균에 대한 녹나무잎 추출물의 항균활성

Jeong-Dan Cha, Mi-Rae Choi, Eun-Sil Ko, Seung-Mi Hwang, Jea-Ran Kang, Joa-Sub Oh, Young-Jin Park, Young-Hwan Jung, Ah-Lim Jeon, Kyung-Min Choi
2015 Korean Journal of Plant Resources  
Methicillin-resistant Staphylococcus aureus (MRSA) has been emerging worldwide as one of the most important hospital and community pathogens. At the same time, because of the difficulty in developing chemical synthetic drugs and because of their side-effects, scientists are making more efforts to search for new drugs from plant resources to combat clinical multidrug-resistant microbial infections. Cinnamomum camphora (C. camphora) is a plant of family Lauraceae, and grown Jeju island in South
more » ... rea that are used as a drug to treat neurasthenia, epilepsy, cystitis, pyelonephritis, digitalis, cancer, and diabetes mellitus in folk remedies. In this study, antibacterial activites of 80% ethanol extract of C. camphora leaves (CCE) were investigated in combination with antibiotics against clinical isolates of MRSA. The results showed that CCE was determined with MIC and MBC values ranging from 156 to 313 and 313 to 625 ㎍/㎖, oxacillin from 128 to 256 and 128 to 512 ㎍/㎖, ampicillin from 4 to 64 and 8 to 128 ㎍/㎖. The combination of CCE with oxacillin or/and ampicillin were synergistic effect against MRSA 1, 6, 7, 8, 10, 11, 12, 13, and 15/ MRSA 1, 2, 6, and 7.
doi:10.7732/kjpr.2015.28.1.009 fatcat:4jt7ut4fa5do5jlvd3g6yukoce