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Synthesis and evaluation of nicotine alpha4beta2 receptor radioligand, 5-(3'-18F-fluoropropyl)-3-(2-(S)-pyrrolidinylmethoxy)pyridine, in rodents and PET in nonhuman primate

Sankha Chattopadhyay, Baogang Xue, Daphne Collins, Rama Pichika, Rudy Bagnera, Frances M Leslie, Bradley T Christian, Bingzhi Shi, Tanjore K Narayanan, Steven G Potkin, Jogeshwar Mukherjee
2005 Journal of Nuclear Medicine  

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Nicotine alpha(4)beta(2) receptor subtypes are implicated in the study of Alzheimer's disease, schizophrenia, substance abuse, lung cancer, and other disorders. We report the development and evaluation of a putative antagonist, 5-(3'-fluoropropyl)-3-(2-(S)-pyrrolidinylmethoxy)pyridine (nifrolidine) as a PET agent for nicotine alpha(4)beta(2) receptors.
pmid:15632043 fatcat:q57xk7xrxza35ouobjw5nrr4ja
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Sankha Chattopadhyay, Baogang Xue, Daphne Collins, Rama Pichika, Rudy Bagnera, Frances M Leslie, Bradley T Christian, Bingzhi Shi, Tanjore K Narayanan, Steven G Potkin, Jogeshwar Mukherjee. "Synthesis and evaluation of nicotine alpha4beta2 receptor radioligand, 5-(3'-18F-fluoropropyl)-3-(2-(S)-pyrrolidinylmethoxy)pyridine, in rodents and PET in nonhuman primate." Journal of Nuclear Medicine 46.1 (2005) 130-40