Proton Pump Inhibitors and Oncologic Treatment Efficacy: A Practical Review of the Literature for Oncologists

Angel A. T. Uchiyama, Pedro A. I. A. Silva, Moisés S. M. Lopes, Cheng T. Yen, Eliza D. Ricardo, Taciana Mutão, Jefferson R. Pimenta, Larissa M. Machado, Denis S. Shimba, Renata D. Peixoto
2021 Current Oncology  
Proton pump inhibitors (PPIs) are the most commonly used anti-acid drugs worldwide, including among cancer patients. However, drug-drug interactions between PPIs and other agents may lead to decreased drug absorption with possible reduced therapeutic benefit, or even increased toxicity. Unfortunately, only scarce data exist regarding the safety of concomitant PPI use with anti-cancer agents. We aim at reviewing current evidence on this possible interaction by dividing anti-cancer agents by
more » ... ncer agents by class. Until further data is available, we encourage healthcare providers to limit unnecessary PPI overuse.
doi:10.3390/curroncol28010076 pmid:33546228 fatcat:jo7sz36rszhepcjfe2jtg2r4wq