Diagnosis and management of Paget?s disease of bone

Luiz Griz, Daniele Fontan, Patricia Mesquita, Marise Lazaretti-Castro, Victoria Zeghbi Cochenski Borba, João Lindolfo Cunha Borges, Thyciara Fontenele, Juliana Maia, Francisco Bandeira
2014 Arquivos brasileiros de endocrinologia e metabologia  
Objective: To conduct a literature review on the diagnosis and management of Paget's disease of bone. Materials and methods: This scientific statement was generated by a request from the Brazilian Medical Association (AMB) to the Brazilian Society of Endocrinology and Metabolism (SBEM) as part of its Clinical Practice Guidelines program. Articles were identified by searching in PubMed and Cochrane databases as well as abstracts presented at the Endocrine Society, Brazilian Society for
more » ... ciety for Endocrinology Annual Meetings and the American Society for Bone and Mineral Research Annual Meeting during the last 5 years. Grading quality of evidence and strength of recommendation were adapted from the first report of the Oxford Centre for Evidence-based Medicine. All grades of recommendation, including "D", are based on scientific evidence. The differences between A, B, C and D, are due exclusively to the methods employed in generating evidence. Conclusion: We present a scientific statement on Paget's disease of bone providing the level of evidence and the degree of recommendation regarding causes, clinical presentation as well as surgical and medical treatment. Arq Bras Endocrinol Metab. 2014;58(6):587-99
doi:10.1590/0004-2730000002941 pmid:25211441 fatcat:iudfyeqgjbgqnk6rhv5vtvrskm